Fig. 1 · Structure
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UP163
VCP Activator
UP163 is a potent valosin-containing protein (VCP) activator that enhances ATPase activity with an EC50 of 9.0 μM. This reagent demonstrates the ability to reduce TDP-43 aggregates induced by MG-132, providing valuable insights into protein homeostasis and neurodegenerative research applications. Its mechanism of action positions UP163 as a key tool for studying VCP-related pathways and their impact on cellular function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 591242-60-3 |
| Applications | VCP Activator |
| Formula | C20H15ClN2O5S |
| Molecular Weight | 430.86 |
| SMILES | O=C(C1=CC=CO1)OCCN(C2=NS(=O)(C3=C2C=CC=C3)=O)C4=CC=C(C=C4)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.