Fig. 1 · Structure
Documents & Downloads
Upacicalcet sodium
Calcimimetic Agent
Upacicalcet sodium is a non-peptide calcimimetic that functions as an agonist of the calcium-sensing receptor (CaSR), with an EC50 value of 10.8 nM. It effectively decreases serum intact parathyroid hormone (iPTH) and calcium levels, alleviating hypocalcemia and associated gastrointestinal complications. In preclinical models of adenine-induced secondary hyperparathyroidism, Upacicalcet sodium has been shown to mitigate vascular calcification and improve bone disorders by inhibiting cortical pore formation and reducing bone fibrosis in chronic kidney disease conditions. This compound serves as a valuable tool for investigating secondary hyperparathyroidism and related bone pathologies.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 2052969-18-1 |
| Applications | Calcimimetic Agent |
| Formula | C11H13ClN3NaO6S |
| Molecular Weight | 373.75 |
| Synonyms | SK-1403; AJT240; PLS240 |
| SMILES | O=C(NC[C@H](N)C(O[Na])=O)NC1=CC(S(=O)(O)=O)=CC(Cl)=C1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.