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Biological Activity
UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines.
| In vitro | DMSO | 22 mg/mL (41.14 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.7 mL | 93.52 mL | 187.03 mL |
| 0.5 mM | 3.74 mL | 18.7 mL | 37.41 mL |
| 1 mM | 1.87 mL | 9.35 mL | 18.7 mL |
| 5 mM | 0.37 mL | 1.87 mL | 3.74 mL |
*The above data is based on the productmolecular weight 534.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A19047 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1890169-95-5 |
| Formula | C25H26N8O2S2 |
| M. Wt | 534.66 |
| Purity | >98% |
| Synonyms | UPGL 00004, UPGL-00004 |
| SMILES | O=C(NC1=NN=C(N2CCC(NC3=NN=C(NC(CC4=CC=CC=C4)=O)S3)CC2)S1)CC5=CC=CC=C5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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Contact information
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