Urocortin II, mouse

Catalog No.: A59731
CRFR Agonist
Urocortin II, mouse is a selective agonist of the type-2 corticotropin-releasing factor (CRF2) receptor, exhibiting a high affinity with a Ki value of 0.66 nM for CRFR2 and over 100 nM for CRFR1. It activates CRF2 receptors via cAMP/PKA and Ca2+/CaMKII signaling pathways. This peptide is predominantly expressed in specific regions of the central nervous system and plays a crucial role in processing visceral sensory information while modulating autonomic functions, making it valuable for research in neurobiology and stress response.
Grouped product items
Size Price Stock Qty
1mg
$100.00
In stock
5mg
$255.00
In stock
10mg
$420.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionUrocortin II, mouse is a selective agonist of the type-2 corticotropin-releasing factor (CRF2) receptor, exhibiting a high affinity with a Ki value of 0.66 nM for CRFR2 and over 100 nM for CRFR1. It activates CRF2 receptors via cAMP/PKA and Ca2+/CaMKII signaling pathways. This peptide is predominantly expressed in specific regions of the central nervous system and plays a crucial role in processing visceral sensory information while modulating autonomic functions, making it valuable for research in neurobiology and stress response.
Product Information
Catalog NumA59731
FormulaC187H320N56O50
Molecular Weight4152.96
CAS Number330648-32-3
SequenceVal-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2
Sequence shorteningVILSLDVPIGLLRILLEQARYKAARNQAATNAQILAHV-NH2
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