Urocortin II, mouse is a selective agonist of the type-2 corticotropin-releasing factor (CRF2) receptor, exhibiting a high affinity with a Ki value of 0.66 nM for CRFR2 and over 100 nM for CRFR1. It activates CRF2 receptors via cAMP/PKA and Ca2+/CaMKII signaling pathways. This peptide is predominantly expressed in specific regions of the central nervous system and plays a crucial role in processing visceral sensory information while modulating autonomic functions, making it valuable for research in neurobiology and stress response.
Urocortin II, mouse is a selective agonist of the type-2 corticotropin-releasing factor (CRF2) receptor, exhibiting a high affinity with a Ki value of 0.66 nM for CRFR2 and over 100 nM for CRFR1. It activates CRF2 receptors via cAMP/PKA and Ca2+/CaMKII signaling pathways. This peptide is predominantly expressed in specific regions of the central nervous system and plays a crucial role in processing visceral sensory information while modulating autonomic functions, making it valuable for research in neurobiology and stress response.
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