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USP1-IN-10

USP1 Inhibitor

USP1-IN-10 is a potent inhibitor of Ubiquitin-Specific Peptidase 1 (USP1), demonstrating an IC50 of 7.6 nM. This tricyclic compound effectively reduces the viability of MDA-MB-436 cancer cells, with an IC50 of 21.58 nM. USP1-IN-10 is valuable for research applications focusing on cancer therapy and the modulation of ubiquitin-mediated protein degradation pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2857051-98-8
Applications	USP1 Inhibitor
Formula	C₂₇H₂₂F₃N₉O
Molecular Weight	545.52
SMILES	COC(N=CN=C1C2CC2)=C1C3=NC=C4C(N(CC5=CC=C(C6=NC(C(F)(F)F)=CN6C)C=C5)C7=CN=CN74)=N3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.