Fig. 1 · Structure
Documents & Downloads
USP7-797
USP7 Inhibitor
USP7-797 is a selective inhibitor of ubiquitin-specific protease 7 (USP7) with an IC50 of 0.5 nmol/L. This compound demonstrates significant antitumor activity by reducing MDM2 levels, which stabilizes and activates p53, promoting cell cycle arrest and apoptosis. USP7-797 exhibits low nanomolar cytotoxicity against both p53 mutant cancer cell lines and p53 wild-type hematological tumors, as well as neuroblastoma cell lines, making it valuable for cancer research applications targeting p53 pathways.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2413944-70-2 |
| Applications | USP7 Inhibitor |
| Formula | C27H28ClN3O3S |
| Molecular Weight | 510.05 |
| Synonyms | USP7-IN-7 |
| SMILES | O=C(N1CC2=CC3=NC=CC(C4=CC(Cl)=CC(C)=C4C[C@@H]5CNCCO5)=C3S2)C6C(C)(C)C6C1=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.