Fig. 1 · Structure
Documents & Downloads
USP7-IN-2
USP7 Inhibitor
USP7-IN-2 is a non-competitive inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an IC50 of 6 nM. This compound promotes the degradation of MDM2, leading to the stabilization of the tumor suppressor protein p53 and the induction of p21 in various cell lines. USP7-IN-2 serves as a valuable tool in cancer research, aiding in the investigation of therapeutic strategies targeting the p53 pathway.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2196243-57-7 |
| Applications | USP7 Inhibitor |
| Formula | C29H34N6O3 |
| Molecular Weight | 514.62 |
| SMILES | O=C1C2=NN(C)C(C3=CC=C(CN)C=C3)=C2N=CN1CC4(O)CCN(C(C[C@H](C5=CC=CC=C5)C)=O)CC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.