Fig. 1 · Structure
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USP8-IN-2
USP8 Inhibitor
USP8-IN-2 is a selective inhibitor of the deubiquitinase USP8, exhibiting an IC50 value of 6.0 μM. This compound demonstrates significant antiproliferative activity in H1957 cells, with a GI50 value of 24.93 μM. USP8-IN-2 is valuable for research applications focused on ubiquitin signaling pathways and their implications in cancer biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2477651-11-7 |
| Applications | USP8 Inhibitor |
| Formula | C19H20ClF3N4OS |
| Molecular Weight | 444.90 |
| SMILES | FC(F)(C1=NC(N2CCC(CC2)NC(NC3=CC(Cl)=CC=C3OC)=S)=CC=C1)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.