V116517 is a potent orally active antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. It effectively inhibits capsaicin- and acid-induced currents in rat dorsal root ganglion neurons expressing native TRPV, with IC50 values of 423.2 nM for capsaicin and 180.3 nM for acid. This compound is valuable for research related to pain mechanisms and potential therapeutic interventions.
V116517 is a potent orally active antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. It effectively inhibits capsaicin- and acid-induced currents in rat dorsal root ganglion neurons expressing native TRPV, with IC50 values of 423.2 nM for capsaicin and 180.3 nM for acid. This compound is valuable for research related to pain mechanisms and potential therapeutic interventions.
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