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Val-Cit-PABC-Ahx-May TFA

Catalog No.: A43182
ADC Linker
Val-Cit-PABC-Ahx-May TFA is a cleavable linker designed for use in the construction of antibody-drug conjugates (ADCs). This compound facilitates targeted drug delivery, allowing for the selective release of therapeutic agents upon internalization by cancer cells. It is particularly valuable in research applications focused on optimizing ADC formulations and enhancing therapeutic efficacy.
Val-Cit-PABC-Ahx-May TFA 2126749-75-3 ADC Linker
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVal-Cit-PABC-Ahx-May TFA is a cleavable linker designed for use in the construction of antibody-drug conjugates (ADCs). This compound facilitates targeted drug delivery, allowing for the selective release of therapeutic agents upon internalization by cancer cells. It is particularly valuable in research applications focused on optimizing ADC formulations and enhancing therapeutic efficacy.
Product Information
Catalog NumA43182
FormulaC59H83ClF3N9O17
Molecular Weight1282.79
CAS Number2126749-75-3
SMILESC[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCCCCNC(OCC5=CC=C(C=C5)NC([C@H](CCCNC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1.OC(C(F)(F)F)=O
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Antibody-drug Conjugates (ADC) > ADC Linker