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Val-Cit-PABC-Ahx-May

Catalog No.: A43171
ADC Linker
Val-Cit-PABC-Ahx-May is a cleavable linker designed for use in antibody-drug conjugates (ADCs). It facilitates the selective release of therapeutics upon internalization by target cells, enhancing the efficacy of targeted cancer therapies. This linker is utilized in research applications focused on the development and optimization of ADCs for improved pharmacokinetics and therapeutic outcomes.
Val-Cit-PABC-Ahx-May 2126749-74-2 ADC Linker
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVal-Cit-PABC-Ahx-May is a cleavable linker designed for use in antibody-drug conjugates (ADCs). It facilitates the selective release of therapeutics upon internalization by target cells, enhancing the efficacy of targeted cancer therapies. This linker is utilized in research applications focused on the development and optimization of ADCs for improved pharmacokinetics and therapeutic outcomes.
Product Information
Catalog NumA43171
FormulaC57H82ClN9O15
Molecular Weight1168.77
CAS Number2126749-74-2
SMILESC[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(CCCCCNC(OCC5=CC=C(C=C5)NC([C@H](CCCNC(N)=O)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1
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Antibody-drug Conjugates (ADC) > ADC Linker