Fig. 1 · Structure
Documents & Downloads
Valategrast hydrochloride
α4β1/α4β7 Antagonist
Valategrast hydrochloride is a potent dual antagonist of the integrins α4β1 (VLA-4) and α4β7. It exhibits significant biological activity in modulating inflammatory responses, making it a candidate for research related to chronic obstructive pulmonary disease (COPD) and asthma treatment. Its ability to inhibit these integrins positions it as a valuable tool for investigating therapeutic strategies targeting immune-mediated disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 828271-96-1 |
| Applications | α4β1/α4β7 Antagonist |
| Formula | C30H33Cl4N3O4 |
| Molecular Weight | 641.41 |
| Synonyms | R-411 |
| SMILES | O=C(OCCN(CC)CC)[C@H](CC1=CC=C(NC(C2=C(Cl)C=CC=C2Cl)=O)C=C1)NC(C3=C(C)C=CC=C3Cl)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.