Fig. 1 · Structure
Documents & Downloads
Valategrast
α4β1/α4β7 Antagonist
Valategrast is a potent oral antagonist of integrins α4β1 and α4β7, which play critical roles in cell adhesion and migration. This compound exhibits significant biological activity in the modulation of inflammatory responses, making it a promising candidate for research related to chronic obstructive pulmonary disease (COPD) and asthma. Its dual targeting mechanism enables exploration of novel therapeutic strategies for managing these respiratory conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 220847-86-9 |
| Applications | α4β1/α4β7 Antagonist |
| Formula | C30H32Cl3N3O4 |
| Molecular Weight | 604.95 |
| Synonyms | R-411 free base |
| SMILES | O=C(OCCN(CC)CC)[C@H](CC1=CC=C(NC(C2=C(Cl)C=CC=C2Cl)=O)C=C1)NC(C3=C(C)C=CC=C3Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.