Valdecoxib-13C2,15N is a stable isotope-labeled derivative of Valdecoxib, a selective and potent inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 5 nM, while displaying significantly lower activity against COX-1 (IC50 of 140 µM). This compound is utilized in pharmacological research to investigate the mechanisms of pain and inflammation, particularly in studies related to arthritis. The incorporation of stable isotopes facilitates advanced analytical techniques such as mass spectrometry in drug metabolism and pharmacokinetics research.
Valdecoxib-13C2,15N is a stable isotope-labeled derivative of Valdecoxib, a selective and potent inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 5 nM, while displaying significantly lower activity against COX-1 (IC50 of 140 µM). This compound is utilized in pharmacological research to investigate the mechanisms of pain and inflammation, particularly in studies related to arthritis. The incorporation of stable isotopes facilitates advanced analytical techniques such as mass spectrometry in drug metabolism and pharmacokinetics research.
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