Valproic acid-d15 is a deuterium-labeled variant of Valproic acid, a known histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. It specifically inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d15 activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. This stable isotope is valuable for pharmacokinetic studies, allowing researchers to trace the metabolic pathways and biological effects of Valproic acid in various therapeutic contexts.
Valproic acid-d15 is a deuterium-labeled variant of Valproic acid, a known histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. It specifically inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d15 activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. This stable isotope is valuable for pharmacokinetic studies, allowing researchers to trace the metabolic pathways and biological effects of Valproic acid in various therapeutic contexts.
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