Valproic acid-d4 is a deuterium-labeled form of Valproic acid, a potent histone deacetylase (HDAC) inhibitor with an IC50 range of 0.5 to 2 mM. This compound specifically inhibits HDAC1 (IC50, 400 μM) and prompts proteasomal degradation of HDAC2. Valproic acid also activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly employed in research pertaining to neurological disorders, including epilepsy and bipolar disorder, as well as in studies investigating its potential for migraine prevention.
Valproic acid-d4 is a deuterium-labeled form of Valproic acid, a potent histone deacetylase (HDAC) inhibitor with an IC50 range of 0.5 to 2 mM. This compound specifically inhibits HDAC1 (IC50, 400 μM) and prompts proteasomal degradation of HDAC2. Valproic acid also activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly employed in research pertaining to neurological disorders, including epilepsy and bipolar disorder, as well as in studies investigating its potential for migraine prevention.
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