Valproic acid-d7 sodium is a deuterium-labeled form of valproic acid sodium salt, an established histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. This compound selectively inhibits HDAC1 (IC50 of 400 μM) and promotes the proteasomal degradation of HDAC2. In addition to its role in modulating HDAC activity, Valproic acid-d7 sodium activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly utilized in research related to epilepsy, bipolar disorder, and migraine prevention.
Valproic acid-d7 sodium is a deuterium-labeled form of valproic acid sodium salt, an established histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. This compound selectively inhibits HDAC1 (IC50 of 400 μM) and promotes the proteasomal degradation of HDAC2. In addition to its role in modulating HDAC activity, Valproic acid-d7 sodium activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly utilized in research related to epilepsy, bipolar disorder, and migraine prevention.
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