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Valproic acid magnesium

HDAC Inhibitor

Valproic acid magnesium is an orally active histone deacetylase (HDAC) inhibitor that exhibits an IC50 range of 0.5 to 2 mM, specifically inhibiting HDAC1 with an IC50 of 400 μM while promoting the proteasomal degradation of HDAC2. This compound activates Notch1 signaling and demonstrates anti-proliferative effects in small cell lung cancer (SCLC) cells. Valproic acid magnesium has diverse therapeutic applications, including the treatment of epilepsy, bipolar disorder, metabolic diseases, HIV infection, and the prevention of migraine headaches.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	62959-43-7
Applications	HDAC Inhibitor
Formula	C₈H₁₅O₂.1/2Mg
Molecular Weight	155.36
Synonyms	Magnesium valproate; VPA magnesium; 2-Propylpentanoic acid magnesium
SMILES	CCCC(CCC)C([O-])=O.[Mg+2]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.