Fig. 1 · Structure
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Vamotinib
Tyrosine Kinase Inhibitor
Vamotinib is a selective and potent orally active tyrosine kinase inhibitor that targets the BCR/ABL fusion protein, including the resistant BCR/ABL-T315I variant. It effectively inhibits autophosphorylation, leading to apoptosis and demonstrating significant anti-proliferative and anti-tumor activities. With low IC50 values across various ABL kinases, Vamotinib holds promise for research applications in Philadelphia chromosome-positive leukemia. Additionally, as a click chemistry reagent featuring an alkyne group, it enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1416241-23-0 |
| Applications | Tyrosine Kinase Inhibitor |
| Formula | C29H27F3N6O |
| Molecular Weight | 532.56 |
| Synonyms | PF-114 |
| SMILES | O=C(C1=CC=C(C)C(C#CC2=NN=C3C=CC=CN23)=C1)NC4=CC=C(CN5CCN(CC5)C)C(C(F)(F)F)=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.