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VDX-111

Necroptosis Inducer

VDX-111 is a necroptosis inducer that functions as an analog of vitamin D. It exerts cytotoxic effects in ovarian cancer cells by upregulating the RIPK1/RIPK3 pathway, leading to necroptotic cell death. Additionally, VDX-111 promotes cytokine expression and demonstrates significant antitumor activity in murine models, making it a valuable tool for cancer research focused on necroptosis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inducer
CAS Number	158983-23-4
Applications	Necroptosis Inducer
Formula	C₂₉H₄₅BrO₄
Molecular Weight	537.57
SMILES	C[C@]([C@@]1([H])[C@H](C)CCCC(C)(O)C)(CCC/2)[C@](CC1)([H])C2=C\C=C(C([C@H]3O)=C)\C[C@H](C3)OC(CBr)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.