Fig. 1 · Structure
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Velnacrine
AChE Inhibitor
Velnacrine is a potent inhibitor of acetylcholinesterase (AChE), displaying an IC50 of 3.27 μM. This compound has demonstrated the ability to reverse scopolamine-induced amnesia in rat models, highlighting its potential in cognitive research. Additionally, Velnacrine exhibits acute toxicity with an LD50 of 65 mg/kg, warranting careful handling during experimental applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 124027-47-0 |
| Applications | AChE Inhibitor |
| Formula | C13H14N2O |
| Molecular Weight | 214.26 |
| Synonyms | HP 029 free base; Hydroxytacrine |
| SMILES | OC1CCCC2=NC3=CC=CC=C3C(N)=C21 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.