In the CORT mouse model of depression, Venlafaxine, EE, and their combination were equally effective in decreasing emotional and cognitive z-scores, with no statistical difference between them. In male BALB/c mice following CT26 inoculation, tumor volume with NE + Venlafaxine was 25.09% of that in the NE group. In another CORT mouse study, Venlafaxine or EE alone tended to lower the proportion of PV+ interneurons enveloped by PNN, but these effects did not reach significance. [1,2]
Literature-reported observations and conditions; not Adooq-tested protocols or general treatment recommendations.
Emotional and cognitive outcomes in CORT model mice
Animal study · Ten-week-old male C57Bl/6Rj mice; CORT mouse model of depression [1]
Male mice in the CORT model of depression received Venlafaxine at 16 mg/kg in drinking water for 8 weeks. Venlafaxine, EE, and their combination were equally effective in decreasing emotional and cognitive z-scores, with no statistical difference between strategies.
Conditions shared by the study groups
- Route
- drinking water
- Treatment course
- 8 weeks of venlafaxine
- Vehicle
- 0.45% β-cyclodextrin
- Venlafaxine 16 mg/kg
- Model: Ten-week-old male C57Bl/6Rj mice; CORT mouse model of depression
Methods and source locations
Compound reported in the paper: Venlafaxine
The paper names Venlafaxine without stating the salt or form; not verified as the hydrochloride form supplied as A10969. No dose conversion or lot validation.
Materials and methods > Animals (S1); Materials and methods > Drugs administration > Corticosterone (CORT) (S11); Materials and methods > Drugs administration > Venlafaxine (VLX) (S12); Results > Long-term treatment with venlafaxine is necessary to induce antidepressant effects (S74); Results > Exposure to enriched environment greatly shortens the time to antidepressant action of venlafaxine (S95, S97); Fig. 1 legend (S135, S141)
emotional z-score: emotional z-score; comparator: CORT-VEH mice, n = 12 — Results > Exposure to enriched environment greatly shortens the time to antidepressant action of venlafaxine (S97); Fig. 1 legend (S141)
Venlafaxine 16 mg/kg · Materials and methods > Drugs administration > Venlafaxine (VLX) (S12); Results > Exposure to enriched environment greatly shortens the time to antidepressant action of venlafaxine (S95, S97)
Venlafaxine with NE and tumor volume in mice
Animal study · male BALB/c mice were randomly divided into four groups (n = 5) [2]
Male BALB/c mice received Venlafaxine at 10 mg/kg intraperitoneally in the NE + VEN group. Following CT26 inoculation, tumor volume in the NE + VEN group was 25.09% of that in the NE group.
Conditions shared by the study groups
- Route
- intraperitoneally
- Treatment course
- every day; One week later; for additional 17 days
- Venlafaxine 10 mg/kg
- Model: male BALB/c mice were randomly divided into four groups (n = 5)
- Reported limits: Not stated in the sentences used: vehicle.
Methods and source locations
Compound reported in the paper: Venlafaxine
The paper names Venlafaxine without stating the salt or form; not verified as the hydrochloride form supplied as A10969. No dose conversion or lot validation.
Results > Venlafaxine antagonizes the NE-promoted colon cancer in vivo and in vitro (S10); Fig. 1 legend (S187, S188, S189, S192)
tumor volume: tumor volume; comparator: NE (0.125 mg/kg) — Results > Venlafaxine antagonizes the NE-promoted colon cancer in vivo and in vitro (S10); Fig. 1 legend (S192)
Venlafaxine 10 mg/kg · Results > Venlafaxine antagonizes the NE-promoted colon cancer in vivo and in vitro (S10); Fig. 1 legend (S187, S188, S189)
PNN enclosure of interneurons in CORT model mice
Animal study · Ten-week-old male C57Bl/6Rj mice; CORT mouse model of depression [1]
Male mice in the CORT model of depression received Venlafaxine at 16 mg/kg in drinking water for 2 weeks. Venlafaxine or EE alone tended to lower the proportion of PV+ interneurons enveloped by PNN, but these effects did not reach significance.
Conditions shared by the study groups
- Route
- drinking water
- Treatment course
- 2 weeks
- Vehicle
- 0.45% β-cyclodextrin
- Venlafaxine 16 mg/kg
- Model: Ten-week-old male C57Bl/6Rj mice; CORT mouse model of depression
Methods and source locations
Compound reported in the paper: Venlafaxine
The paper names Venlafaxine without stating the salt or form; not verified as the hydrochloride form supplied as A10969. No dose conversion or lot validation.
Materials and methods > Animals (S1); Materials and methods > Drugs administration > Corticosterone (CORT) (S11); Materials and methods > Drugs administration > Venlafaxine (VLX) (S12); Results > The antidepressant action requires the remodeling of the extracellular matrix surrounding hippocampal interneurons (S102, S105); Fig. 2 legend (S147, S148, S149)
Proportion of PV+/PNN+ cells among PV+ cells in CA1: Proportion of PV+/PNN+ cells among PV+ cells in CA1; comparator: CORT-VEH mice, n = 6 — Results > The antidepressant action requires the remodeling of the extracellular matrix surrounding hippocampal interneurons (S105); Fig. 2 legend (S149)
Venlafaxine 16 mg/kg · Materials and methods > Drugs administration > Venlafaxine (VLX) (S12); Results > The antidepressant action requires the remodeling of the extracellular matrix surrounding hippocampal interneurons (S105); Fig. 2 legend (S147, S148)
