Fig. 1 · Structure
Documents & Downloads
Verubecestat tosylate
BACE1/2 Inhibitor
Verubecestat tosylate is a potent inhibitor of BACE1 and BACE2, displaying high affinity with Ki values of 2.2 nM and 0.38 nM, respectively. This compound effectively reduces levels of Aβ40, making it a potential therapeutic agent for Alzheimer's Disease research. Verubecestat tosylate is utilized in studies exploring the modulation of amyloid-beta peptide production and its implications in neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1875153-95-9 |
| Applications | BACE1/2 Inhibitor |
| Formula | C24H25F2N5O6S2 |
| Molecular Weight | 581.61 |
| Synonyms | MK-8931 tosylate |
| SMILES | O=S(O)(C1=CC=C(C=C1)C)=O.C[C@]2(CS(=O)(N(C(N)=N2)C)=O)C3=CC(NC(C4=CC=C(C=N4)F)=O)=CC=C3F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.