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VHL Ligand intermediate-1

Intermediate

VHL Ligand Intermediate-1 is a crucial synthetic intermediate in the production of VHL E3 ubiquitin ligase ligands. This compound facilitates the development of proteolysis targeting chimeras (PROTACs), which harness the ubiquitin-proteasome system for targeted protein degradation. Its key role in the synthesis of these ligands makes it valuable for research applications focused on targeted therapy and drug discovery.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2380273-21-0
Applications	Intermediate
Formula	C₂₂H₂₉N₃O₄S
Molecular Weight	431.55
SMILES	C[C@@H](C1=CC=C(C2=C(N=CS2)C)C=C1)NC([C@H]3N(C[C@H](C3)O)C(OC(C)(C)C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.