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VHL Ligand intermediate-2

Intermediate

VHL Ligand intermediate-2 (compound 18c) functions as a critical intermediate in the synthesis of VHL E3 ubiquitin ligase ligands. This compound is essential for the development of proteolysis-targeting chimeras (PROTACs), which are valuable tools for targeted protein degradation studies. Its application in chemical biology enables researchers to explore innovative therapeutic strategies through modulation of the ubiquitin-proteasome system.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2380273-24-3
Applications	Intermediate
Formula	C₂₈H₄₀N₄O₅S
Molecular Weight	544.71
SMILES	CC(C)(C)OC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.