Fig. 1 · Structure
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Viloxazine hydrochloride
Norepinephrine Reuptake Inhibitor
Viloxazine hydrochloride is a selective norepinephrine transporter (NET) inhibitor with an IC50 of 0.26 μM, functioning primarily to elevate norepinephrine levels in the synaptic cleft. Additionally, it modulates serotonin receptor activity by antagonizing 5-HT2B receptors (Ki=4.2 μM) and agonizing 5-HT2C receptors (EC50=32 μM), thereby enhancing serotonin neurotransmission. This compound is utilized in research related to attention deficit hyperactivity disorder (ADHD) and offers insights into the modulation of noradrenergic and serotonergic systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 35604-67-2 |
| Applications | Norepinephrine Reuptake Inhibitor |
| Formula | C13H20ClNO3 |
| Molecular Weight | 273.76 |
| Synonyms | Viloxazin hydrochloride; Emovit hydrochloride |
| SMILES | CCOC1=C(OCC2OCCNC2)C=CC=C1.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.