Fig. 1 · Structure
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Viloxazine
Norepinephrine Reuptake Inhibitor
Viloxazine is a selective norepinephrine transporter (NET) inhibitor, exhibiting an IC50 value of 0.26 μM. It demonstrates dual activity as a 5-HT receptor modulator by antagonizing 5-HT2B receptors (Ki = 4.2 μM) and agonizing 5-HT2C receptors (EC50 = 32 μM), thereby enhancing serotonin neurotransmission. Viloxazine effectively increases levels of norepinephrine and dopamine in the synaptic cleft, making it a valuable reagent for researching attention deficit hyperactivity disorder (ADHD) and related neurochemical pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 46817-91-8 |
| Applications | Norepinephrine Reuptake Inhibitor |
| Formula | C13H19NO3 |
| Molecular Weight | 237.29 |
| Synonyms | Viloxazin; Emovit |
| SMILES | CCOC1=C(C=CC=C1)OCC2OCCNC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.