Vinclozolin M2 is an active metabolite of vinclozolin, primarily functioning as an antagonist of the mineralocorticoid receptor (IC50 = 1,400 nM) and the androgen receptor (IC50 = 0.17 nM). This compound is obtained through esterase activity and decarboxylation processes in C. elegans and human liver microsomes. Vinclozolin M2 exhibits significant biological activity, making it useful for investigating receptor-mediated signaling pathways and studying endocrine disruption in parasitic and mammalian systems.
Vinclozolin M2 is an active metabolite of vinclozolin, primarily functioning as an antagonist of the mineralocorticoid receptor (IC50 = 1,400 nM) and the androgen receptor (IC50 = 0.17 nM). This compound is obtained through esterase activity and decarboxylation processes in C. elegans and human liver microsomes. Vinclozolin M2 exhibits significant biological activity, making it useful for investigating receptor-mediated signaling pathways and studying endocrine disruption in parasitic and mammalian systems.
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