Vobarilizumab (ALX-0061) is a humanized bispecific monoclonal antibody that targets both the interleukin-6 receptor (IL-6R) and human serum albumin (ALB) with a dissociation constant (Kd) of 0.19 pM. This antibody features distinct domains: one that binds to IL-6R and another that binds to human serum albumin. The dual specificity of Vobarilizumab allows for enhanced targeting and retention in the human body, making it a valuable tool in the study of inflammatory autoimmune conditions, including rheumatoid arthritis. This antibody's unique configuration and high affinity make it ideal for research applications focused on the pathogenesis and treatment strategies of such diseases.
Vobarilizumab (ALX-0061) is a humanized bispecific monoclonal antibody that targets both the interleukin-6 receptor (IL-6R) and human serum albumin (ALB) with a dissociation constant (Kd) of 0.19 pM. This antibody features distinct domains: one that binds to IL-6R and another that binds to human serum albumin. The dual specificity of Vobarilizumab allows for enhanced targeting and retention in the human body, making it a valuable tool in the study of inflammatory autoimmune conditions, including rheumatoid arthritis. This antibody's unique configuration and high affinity make it ideal for research applications focused on the pathogenesis and treatment strategies of such diseases.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
Please check COA/MSDS for correct molecular weight.
Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
Frequently Asked Questions
What are Biosimilar Antibodies?
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research.
Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
