Vortioxetine-d3 is a stable isotope labeled derivative of Vortioxetine, which primarily acts as an antagonist of the 5-HT3A and 5-HT7 receptors, exhibiting high affinity with Ki values of 3.7 nM and 19 nM, respectively. Additionally, it serves as a potent inhibitor of the serotonin transporter (SERT) with a Ki of 1.6 nM, and functions as a 5-HT1A agonist and a partial agonist at the 5-HT1B receptor, showing Ki values of 15 nM and 33 nM. This compound is valuable for pharmacokinetic studies and research related to serotonin modulation in various neurological and psychiatric disorders.
Vortioxetine-d3 is a stable isotope labeled derivative of Vortioxetine, which primarily acts as an antagonist of the 5-HT3A and 5-HT7 receptors, exhibiting high affinity with Ki values of 3.7 nM and 19 nM, respectively. Additionally, it serves as a potent inhibitor of the serotonin transporter (SERT) with a Ki of 1.6 nM, and functions as a 5-HT1A agonist and a partial agonist at the 5-HT1B receptor, showing Ki values of 15 nM and 33 nM. This compound is valuable for pharmacokinetic studies and research related to serotonin modulation in various neurological and psychiatric disorders.
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