VU0360172 is a selective positive allosteric modulator of the mGlu5 receptor, exhibiting an EC50 of 16 nM and a Ki of 195 nM. It effectively stimulates polyphosphoinositide (PI) hydrolysis in vivo, an action that is absent in mice lacking the mGlu5 receptor gene. Additionally, VU0360172 features an alkyne group, facilitating its use as a click chemistry reagent that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various biochemical applications.
VU0360172 is a selective positive allosteric modulator of the mGlu5 receptor, exhibiting an EC50 of 16 nM and a Ki of 195 nM. It effectively stimulates polyphosphoinositide (PI) hydrolysis in vivo, an action that is absent in mice lacking the mGlu5 receptor gene. Additionally, VU0360172 features an alkyne group, facilitating its use as a click chemistry reagent that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various biochemical applications.
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