Fig. 1 · Structure
Documents & Downloads
VU0360172
mGlu5 Receptor PAM
VU0360172 is a selective positive allosteric modulator of the mGlu5 receptor, exhibiting an EC50 of 16 nM and a Ki of 195 nM. It effectively stimulates polyphosphoinositide (PI) hydrolysis in vivo, an action that is absent in mice lacking the mGlu5 receptor gene. Additionally, VU0360172 features an alkyne group, facilitating its use as a click chemistry reagent that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, making it valuable for various biochemical applications.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1310012-12-4 |
| Applications | mGlu5 Receptor PAM |
| Formula | C18H15FN2O |
| Molecular Weight | 294.32 |
| SMILES | O=C(NC1CCC1)C2=CC=C(N=C2)C#CC3=CC=CC(F)=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.