VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4). It demonstrates effective modulation with EC50 values of 290 nM for rat mGlu4 and 1.1 μM for human mGlu4, while also exhibiting antagonist activity against mGlu5 and PAM activity at mGlu6. Additionally, VU0364770 hydrochloride shows inhibition of monoamine oxidase with Ki values of 8.5 μM for human MAO-A and 0.72 μM for human MAO-B, making it valuable for research in neuropharmacology and related fields.
VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGlu4). It demonstrates effective modulation with EC50 values of 290 nM for rat mGlu4 and 1.1 μM for human mGlu4, while also exhibiting antagonist activity against mGlu5 and PAM activity at mGlu6. Additionally, VU0364770 hydrochloride shows inhibition of monoamine oxidase with Ki values of 8.5 μM for human MAO-A and 0.72 μM for human MAO-B, making it valuable for research in neuropharmacology and related fields.
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