Fig. 1 · Structure
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VU0366369
mAChR M1 Modulator
VU0366369 is a selective positive allosteric modulator (PAM) of the muscarinic acetylcholine receptor subtype M1, exhibiting an EC50 value of 830 nM. This compound has demonstrated potential for enhancing M1 receptor function, making it a valuable tool in the study of central nervous system disorders. Researchers may utilize VU0366369 to explore therapeutic strategies for conditions such as Alzheimer's disease and schizophrenia, focusing on cholinergic signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1222834-53-8 |
| Applications | mAChR M1 Modulator |
| Formula | C19H14FN3O2 |
| Molecular Weight | 335.33 |
| Synonyms | ML137 |
| SMILES | O=C1C(N(CC2=C(F)C=C(C3=CN(C)N=C3)C=C2)C4=C1C=CC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.