VU0448088 is a potent positive allosteric modulator targeting the M4 muscarinic acetylcholine receptor, demonstrating EC50 values of 56 nM and 176 nM for human and rat receptors, respectively. This tricyclic compound effectively crosses the blood-brain barrier, making it a valuable tool for investigating neuropsychiatric conditions, particularly those related to psychosis. Its ability to enhance M4 receptor activity highlights its potential in research applications focused on neuromodulation and cognitive function.
VU0448088 is a potent positive allosteric modulator targeting the M4 muscarinic acetylcholine receptor, demonstrating EC50 values of 56 nM and 176 nM for human and rat receptors, respectively. This tricyclic compound effectively crosses the blood-brain barrier, making it a valuable tool for investigating neuropsychiatric conditions, particularly those related to psychosis. Its ability to enhance M4 receptor activity highlights its potential in research applications focused on neuromodulation and cognitive function.
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