VU0467485 is a potent and selective positive allosteric modulator of the muscarinic acetylcholine receptor 4 (M4). It enhances acetylcholine activity at M4 receptors, exhibiting EC50 values of 26.6 nM in rat and 78.8 nM in human systems. VU0467485 shows high selectivity for M4 over the other muscarinic receptor subtypes (M1, M2, M3, and M5) in both human and rat samples. This compound also demonstrates moderate to high central nervous system penetration and possesses antipsychotic-like properties, making it a valuable tool for the study of neurological disorders.
VU0467485 is a potent and selective positive allosteric modulator of the muscarinic acetylcholine receptor 4 (M4). It enhances acetylcholine activity at M4 receptors, exhibiting EC50 values of 26.6 nM in rat and 78.8 nM in human systems. VU0467485 shows high selectivity for M4 over the other muscarinic receptor subtypes (M1, M2, M3, and M5) in both human and rat samples. This compound also demonstrates moderate to high central nervous system penetration and possesses antipsychotic-like properties, making it a valuable tool for the study of neurological disorders.
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