Fig. 1 · Structure
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VU0486846
M1 Positive Allosteric Modulator
VU0486846 is a selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor. This compound enhances receptor activity in a manner dependent on the presence of the endogenous ligand. VU0486846 is utilized in research to explore its potential therapeutic effects in cognitive disorders and neurodegenerative diseases. Its oral bioavailability makes it a valuable tool for in vivo studies of M1 modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1788055-11-7 |
| Applications | M1 Positive Allosteric Modulator |
| Formula | C25H28N4O3 |
| Molecular Weight | 432.51 |
| SMILES | O[C@@H](CCCC1)[C@H]1NC([C@@H](C2)OC3=CC=CC=C3N2CC4=CC=C(N5C=CC=N5)C=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.