Fig. 1 · Structure
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VU6000918
M4 Positive Allosteric Modulator
VU6000918 is a positive allosteric modulator of the muscarinic acetylcholine receptor M4, demonstrating an EC50 of 19 nM for human M4. This compound enhances the receptor's activity in response to acetylcholine, making it a valuable tool for studying M4 receptor function. VU6000918 can be utilized in research related to neurological disorders and cognitive functions, providing insights into the therapeutic potential of modulating M4 receptor signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 2101737-32-8 |
| Applications | M4 Positive Allosteric Modulator |
| Formula | C18H17F2N5OS |
| Molecular Weight | 389.42 |
| SMILES | O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NC3CN(C4=CC=CC(F)=C4F)C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.