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Biological Activity
VU6005806 (AZN-00016130) is a potent muscarnic acethylcholine receptor subtype 4 (M4) positive allosteric modulator (PAM), with EC50s of 94 nM, 28 nM, 87 nM and 68 nM for human, rat, dog and cyno M4, respectively. Used in the research of neuropsychiatric disorders.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.76 mL | 113.79 mL | 227.58 mL |
| 0.5 mM | 4.55 mL | 22.76 mL | 45.52 mL |
| 1 mM | 2.28 mL | 11.38 mL | 22.76 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.55 mL |
*The above data is based on the productmolecular weight 439.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18488 |
|---|---|
| Actions | Modulator |
| CAS No. | 2180914-37-6 |
| Formula | C17H16F3N7O2S |
| M. Wt | 439.41 |
| Purity | >98% |
| Synonyms | VU 6005806, VU-6005806, AZN00016130, AZN 00016130 |
| SMILES | NC1=C(C(NC2CN(C3=NC=C(C(F)(F)F)C=N3)C2)=O)SC4=NN=C(OC)C(C)=C41 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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