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VU6009453

Catalog No.: A61416
M4 mAChR PAM
VU6009453 is a positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (mAChR), exhibiting an EC50 of 383 nM. This compound effectively enhances M4 receptor activity and is valuable for research focused on neurological disorders. Its ability to penetrate the blood-brain barrier makes it a pertinent tool in studies investigating potential therapeutic strategies for conditions related to M4 mAChR function.
VU6009453 2148929-11-5 M4 mAChR PAM
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionVU6009453 is a positive allosteric modulator (PAM) of the M4 muscarinic acetylcholine receptor (mAChR), exhibiting an EC50 of 383 nM. This compound effectively enhances M4 receptor activity and is valuable for research focused on neurological disorders. Its ability to penetrate the blood-brain barrier makes it a pertinent tool in studies investigating potential therapeutic strategies for conditions related to M4 mAChR function.
Product Information
Catalog NumA61416
FormulaC21H21ClN4O2
Molecular Weight396.88
CAS Number2148929-11-5
SMILESO=C(NC1CN(C2=CC(=NC=C2Cl)OC)C1)C=3C=CC=4N=C(C=C(C4C3)C)C
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Neuronal Signaling > mAChR