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VU6052254

M1 Positive Allosteric Modulator

VU6052254 is a selective, potent positive allosteric modulator of the muscarinic M1 acetylcholine receptor, exhibiting an EC50 of 59 nM. This compound demonstrates no activity on M2-5 receptors, ensuring specificity in its mechanism of action. VU6052254 enhances memory recognition and effectively reverses cognitive impairments induced by scopolamine at a minimum effective dose of 1 mg/kg. It is a valuable tool for researching neurological disorders, including Alzheimer's disease, facilitating investigations into cognitive enhancement strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	3035701-02-8
Applications	M1 Positive Allosteric Modulator
Formula	C₂₅H₂₂F₂N₄O₂
Molecular Weight	448.46
SMILES	FC1=CC(C2=CC=C(C(C)(O)C)C3=NN(C)C=C32)=CC(F)=C1CN4C(C5=CC=CN=C5C4)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.