VUF10166 is a potent 5-HT3 receptor antagonist, exhibiting high affinity with Ki values of 0.04 nM for the 5-HT3A subtype and 22 nM for the 5-HT3AB subtype. This compound effectively inhibits 5-HT-induced responses at these receptors at nanomolar concentrations. Additionally, at elevated concentrations, VUF10166 demonstrates partial agonistic activity at the 5-HT3 receptor, with an EC50 of 5.2 μM. Its unique pharmacological profile makes it a valuable tool for research in neurobiology and gastrointestinal pharmacology.
VUF10166 is a potent 5-HT3 receptor antagonist, exhibiting high affinity with Ki values of 0.04 nM for the 5-HT3A subtype and 22 nM for the 5-HT3AB subtype. This compound effectively inhibits 5-HT-induced responses at these receptors at nanomolar concentrations. Additionally, at elevated concentrations, VUF10166 demonstrates partial agonistic activity at the 5-HT3 receptor, with an EC50 of 5.2 μM. Its unique pharmacological profile makes it a valuable tool for research in neurobiology and gastrointestinal pharmacology.
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