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VX-148

IMPDH Inhibitor

VX-148 is a non-competitive inhibitor of inosine-5'-monophosphate dehydrogenase (IMPDH), targeting both IMPDH I and II with Ki values of 14 nM and 6 nM, respectively. This compound effectively suppresses the proliferation of activated human peripheral blood mononuclear cells (PBMCs) induced by T-cell mitogen (PHA) or B-cell mitogen (SPAS), demonstrating high selectivity for lymphocytes, including L1210, Jurkat T cells, and Raji B cells, while sparing non-lymphoid cells from significant toxicity. VX-148 has applications in the study of autoimmune diseases such as rheumatoid arthritis and psoriasis, as well as in organ transplantation to prevent acute rejection.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	297730-05-3
Applications	IMPDH Inhibitor
Formula	C₂₃H₂₅N₅O₄
Molecular Weight	435.48
SMILES	O=C(O[C@@H](CC#N)CC)N[C@H](C1=CC=CC(NC(NC2=CC=C(C#N)C(OC)=C2)=O)=C1)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.