Fig. 1 · Structure
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W-7 hydrochloride
Calmodulin Antagonist
W-7 hydrochloride is a selective calmodulin antagonist that functions by inhibiting calcium-calmodulin-dependent pathways. It effectively inhibits phosphodiesterase and myosin light chain kinase, demonstrating IC50 values of 28 μM and 51 μM, respectively. Additionally, W-7 hydrochloride induces apoptosis and exhibits antitumor and vascular relaxing properties. Furthermore, it acts as a blocker of Kv4.3, making it a valuable tool for research into arrhythmias and related cardiovascular studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 61714-27-0 |
| Applications | Calmodulin Antagonist |
| Formula | C16H22Cl2N2O2S |
| Molecular Weight | 377.33 |
| SMILES | O=S(C1=C2C=CC=C(Cl)C2=CC=C1)(NCCCCCCN)=O.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.