Fig. 1 · Structure
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W-84 dibromide
M2 Cholinoceptors Allosteric Modulator
W-84 dibromide is a potent allosteric modulator of M2 cholinoceptors, effectively retarding the dissociation of [3H]N-methylscopolamine. This compound stabilizes the complexes formed between cholinergic antagonists and receptors, exhibiting non-competitive antagonism at muscarinic acetylcholine receptors. W-84 dibromide demonstrates protective effects against organophosphate intoxication when administered in conjunction with atropine, making it a valuable tool in neuropharmacological research and studies related to cholinergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 21093-51-6 |
| Applications | M2 Cholinoceptors Allosteric Modulator |
| Formula | C32H44Br2N4O4 |
| Molecular Weight | 708.52 |
| Synonyms | HDMPPA |
| SMILES | C[N+](C)(CCCN(C(C1=C2C=CC=C1)=O)C2=O)CCCCCC[N+](C)(CCCN(C(C3=C4C=CC=C3)=O)C4=O)C.[Br-].[Br-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.