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Wee1/HDAC-IN-1

Wee1/HDAC Inhibitor

Wee1/HDAC-IN-1 is a dual inhibitor targeting Wee1 and histone deacetylases (HDACs). It demonstrates potent activity with an IC50 of 1.2 nM for Wee1 and varying IC50 values of 196 nM for HDAC1, 156 nM for HDAC3, and 55 nM for HDAC6. This compound displays significant antiproliferative effects in MV4-11 cells, with an IC50 of 0.076 μM, by disrupting DNA damage repair mechanisms and promoting apoptosis. Wee1/HDAC-IN-1 is suited for research on acute myeloid leukemia (AML).

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3037071-29-4
Applications	Wee1/HDAC Inhibitor
Formula	C₃₃H₄₃N₉O₄
Molecular Weight	629.75
SMILES	O=C1N(N(C2=NC(NC3=CC=C(C=C3)N4CCN(CC4)CCCCCCC(NO)=O)=NC=C21)C5=NC(C(O)(C)C)=CC=C5)CC=C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.