WEE1-IN-12 is a potent Wee1 kinase inhibitor with an IC50 of 2.0 nM. It demonstrates significant antiproliferative effects in HT29 colorectal cancer cells, exhibiting an IC50 of 1.07 μM. The compound enhances the efficacy of Gemcitabine, showing improved activity with an IC50 of 0.34 μM in combination studies. WEE1-IN-12 is valuable for research into targeted therapies for tumors, particularly colon cancer.
WEE1-IN-12 is a potent Wee1 kinase inhibitor with an IC50 of 2.0 nM. It demonstrates significant antiproliferative effects in HT29 colorectal cancer cells, exhibiting an IC50 of 1.07 μM. The compound enhances the efficacy of Gemcitabine, showing improved activity with an IC50 of 0.34 μM in combination studies. WEE1-IN-12 is valuable for research into targeted therapies for tumors, particularly colon cancer.
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