Fig. 1 · Structure
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WIN 51708
NK-1 Receptor Antagonist
WIN 51708 is a nonpeptide antagonist of the neurokinin-1 (NK-1) receptor, predominantly exhibiting higher affinity for the rat NK-1 receptor than the human variant. This compound serves as a valuable tool in research aimed at understanding pain modulation and neurogenic inflammation. Its application can extend to studies investigating pain pathways and the potential therapeutic roles of NK-1 receptor antagonism in various neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 144177-30-0 |
| Applications | NK-1 Receptor Antagonist |
| Formula | C29H33N3O |
| Molecular Weight | 439.59 |
| SMILES | C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])CC4=NC5=NC6=CC=CC=C6N5C=C4C2)([H])[C@@]7([H])[C@](CC3)([C@@](O)(CC7)C#C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.