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WIN 64338 hydrochloride

Bradykinin B2 Receptor Antagonist

WIN 64338 hydrochloride is a selective, nonpeptide competitive antagonist of the bradykinin B2 receptor, effectively inhibiting [3H]-Bradykinin binding in human IMR-90 cells with a Ki value of 64 nM. Additionally, this compound demonstrates inhibitory effects on [3H]Quinuclidinyl benzilate binding to rat brain muscarinic receptors, with a Ki of 350 nM. Its ability to modulate bradykinin signaling positions WIN 64338 hydrochloride as a valuable tool for research in pain, inflammation, and cardiovascular studies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	163727-74-0
Applications	Bradykinin B2 Receptor Antagonist
Formula	C₄₅H₆₉Cl₂N₄OP
Molecular Weight	783.94
SMILES	O=C(NC1=CC=C(C[P+](CCCC)(CCCC)CCCC)C=C1)[C@@H](/N=C(NC2CCCCC2)/NC3CCCCC3)CC4=CC=C5C=CC=CC5=C4.[Cl-].Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.