WKYMVM-NH2 is a hexapeptide that acts as an agonist for the FPRL1 and FPRL2 receptors, primarily activating neutrophils and myeloid cells. Its potent biological activity is characterized by EC50 values of 2 nM and 80 nM in HL-60 cells expressing FPRL1 and FPRL2, respectively. WKYMVM-NH2 induces chemotaxis in HL-60-FPRL2 cells, with optimal migration observed between 10 and 50 nM, and significantly stimulates superoxide production in neutrophils with an EC50 of 75 nM. This peptide serves as a valuable tool for studying inflammatory diseases and related mechanisms.
WKYMVM-NH2 is a hexapeptide that acts as an agonist for the FPRL1 and FPRL2 receptors, primarily activating neutrophils and myeloid cells. Its potent biological activity is characterized by EC50 values of 2 nM and 80 nM in HL-60 cells expressing FPRL1 and FPRL2, respectively. WKYMVM-NH2 induces chemotaxis in HL-60-FPRL2 cells, with optimal migration observed between 10 and 50 nM, and significantly stimulates superoxide production in neutrophils with an EC50 of 75 nM. This peptide serves as a valuable tool for studying inflammatory diseases and related mechanisms.
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