WLB-89462 is a selective σ2 receptor ligand, exhibiting an affinity (Ki) of 13 nM. This compound demonstrates neuroprotective activity, effectively improving short-term memory impairment caused by Aβ peptide in rodent models. Additionally, WLB-89462 possesses a favorable ADMET profile, characterized by good solubility, lack of CYP inhibition, metabolic stability, high permeability, and significant brain penetration, making it a valuable tool for research in neurodegenerative diseases.
WLB-89462 is a selective σ2 receptor ligand, exhibiting an affinity (Ki) of 13 nM. This compound demonstrates neuroprotective activity, effectively improving short-term memory impairment caused by Aβ peptide in rodent models. Additionally, WLB-89462 possesses a favorable ADMET profile, characterized by good solubility, lack of CYP inhibition, metabolic stability, high permeability, and significant brain penetration, making it a valuable tool for research in neurodegenerative diseases.
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